Anti-RANKL antibody was approved for the treatment of osteoporosis in Japan
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متن کاملAdministration of anti-receptor activator of nuclear factor-kappa B ligand (RANKL) antibody for the treatment of osteoporosis was associated with amelioration of hepatitis in a female patient with growth hormone deficiency: a case report
BACKGROUND Growth hormone deficiency (GHD) is associated with non-alcoholic fatty liver disease (NAFLD). A recent animal study showed that hepatocyte-specific receptor activator of nuclear factor-kappa B (RANK) knockout mice had significantly lower liver fat content compared with control mice concomitant with a decrease in production of inflammatory cytokines such as tumor necrosis factor-α (TN...
متن کاملRole of RANKL inhibition in osteoporosis
When the rate of bone resorption exceeds that of bone formation, destruction of bone tissue occurs, resulting in a fragile skeleton. The clinical consequences, namely osteoporosis and fragility fractures, are common and costly problems. Treatments that normalize the balance of bone turnover by inhibiting bone resorption preserve bone mass and reduce fracture risk. The discovery of receptor acti...
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ژورنال
عنوان ژورنال: Japanese Journal of Clinical Immunology
سال: 2013
ISSN: 0911-4300,1349-7413
DOI: 10.2177/jsci.36.209